ERC2-IT1

Across TCGA pan-cancer cohorts, ERC2-IT1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ERC2-IT1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ERC2-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERC2-IT1 expression acts as an unfavorable survival marker, although some lineages such as CESC and THCA show a favorable association.

UVM, CESC, and READ are the cancer types where ERC2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.148	0.776	<.001	57	view →
CESC	OS	Tertile	All	0.916	0.762	.008	52	view →
READ	DFS	Tertile	All	0.166	0.615	<.001	33	view →
THCA	DFS	Tertile	All	0.935	0.799	.024	24	view →
SKCM	DFS	Quartile	All	0.327	0.175	.001	18	view →
BRCA	OS	Tertile	III,IV	0.978	0.887	.013	18	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	18	view →
DLBC	DFS	Median	II,III,IV	0.908	0.461	.005	17	view →
KICH	DFS	Tertile	All	0.308	0.869	.003	12	view →
LUAD	DFS	Tertile	III,IV	0.684	0.296	.022	12	view →
LUSC	DFS	Quartile	All	0.842	0.730	.009	11	view →
THYM	OS	Median	All	1.000	0.663	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ERC2-IT1–UVM (DFS)

Open the UVM breakdown →