ERC1

Across TCGA patient cohorts, ERC1 mutation is significantly associated with the RNA expression of many other genes, with 3,964 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERC1-associated genes across cancer lineages are MIR4443, RNU6-1178P, and TMEM62. Each is linked with ERC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERC1-to-partner and partner-to-ERC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4443 grouped by ERC1-low versus ERC1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERC1→partner) and Y-score (partner→ERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4443 →	+0.280	+4.221	<.001	.008	3	3
LIHC	RNU6-1178P →	+0.756	+4.108	<.001	.002	3	3
UCEC	TMEM62 →	+0.454	+1.839	<.001	.002	3	3
UCEC	RN7SL649P →	+0.104	+1.652	<.001	.008	3	3
UCEC	DEFB108E →	+0.051	+3.111	<.001	.003	3	3
BLCA	LINC01757 →	+0.090	+4.177	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,964 associations by consensus.

MIR4443 by ERC1 expression — HNSC

Explore this box plot interactively →