ERAP1

Across TCGA cell cohorts, ERAP1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERAP1-associated genes across cancer lineages are TNFSF13B, TDRD10, and OTOP1. Each is linked with ERAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERAP1-to-partner and partner-to-ERAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNFSF13B grouped by ERAP1-low versus ERAP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERAP1→partner) and Y-score (partner→ERAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNFSF13B →	+0.510	+3.215	.002	.009	3	1
LARGE_INTESTINE	TDRD10 →	+0.077	+3.363	<.001	<.001	3	1
LARGE_INTESTINE	OTOP1 →	+0.529	+3.025	<.001	.002	3	1
LARGE_INTESTINE	FASN →	+0.851	+3.067	.002	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
LARGE_INTESTINE	C14orf180 →	+0.110	+2.892	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TNFSF13B by ERAP1 expression — LARGE_INTESTINE

Explore this box plot interactively →