EPS8L2

Across TCGA patient cohorts, EPS8L2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPS8L2-associated genes across cancer lineages are ATM, Notch1, and Smad1. Each is linked with EPS8L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPS8L2-to-partner and partner-to-EPS8L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EPS8L2-low versus EPS8L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS8L2→partner) and Y-score (partner→EPS8L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.486	-2.000	.017	.032	3	3
UCEC	Notch1 →	+0.168	+3.331	.008	.005	3	2
UCEC	Smad1 →	-0.155	-3.000	.028	.036	3	1
UCEC	TIGAR →	+0.179	+2.026	.009	.018	3	1
UCEC	4E-BP1 →	+0.335	+3.029	.006	.018	3	1
UCEC	ERK2 →	+0.230	+2.700	.007	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ATM by EPS8L2 expression — UCEC

Explore this box plot interactively →