EPS8L2

Across TCGA pan-cancer cohorts, EPS8L2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EPS8L2 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher EPS8L2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated EPS8L2 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

UVM, LGG, and LIHC are the cancer types where EPS8L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	1.000	0.681	.001	81	view →
LGG	DFS	Median	All	0.646	0.811	<.001	54	view →
LIHC	OS	Quartile	II,III,IV	0.577	0.792	.008	38	view →
ACC	DFS	Quartile	II,III,IV	0.123	0.717	.001	36	view →
GBM	OS	Tertile	All	0.197	0.337	<.001	33	view →
KIRP	OS	Quartile	II,III,IV	0.957	0.595	.003	29	view →
CHOL	DFS	Median	All	0.759	0.123	.005	23	view →
LUSC	DFS	Median	All	0.608	0.706	.008	19	view →
LAML	DFS	Tertile	All	0.287	0.479	.023	16	view →
PRAD	DFS	Tertile	All	0.846	0.951	<.001	16	view →
THCA	DFS	Quartile	III,IV	0.518	0.907	.006	13	view →
CESC	DFS	Quartile	All	0.412	0.715	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EPS8L2–UVM (OS)

Open the UVM breakdown →