EPS8L2

Across TCGA cell cohorts, EPS8L2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EPS8L2-associated genes across cancer lineages are OR10A4, OR2A4, and DYTN. Each is linked with EPS8L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPS8L2-to-partner and partner-to-EPS8L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A4 grouped by EPS8L2-low versus EPS8L2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS8L2→partner) and Y-score (partner→EPS8L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10A4 →	+0.039	+4.295	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR2A4 →	+0.048	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	DYTN →	+0.022	+3.734	.002	.006	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.011	+4.078	<.001	.009	3	1
BLOOD_Leukemia	UCP1 →	+0.159	+4.321	.006	.001	3	1
BLOOD_Leukemia	OR11H1 →	+0.068	+4.201	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

OR10A4 by EPS8L2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →