EPS8

Across TCGA patient cohorts, EPS8 mutation is significantly associated with the RNA expression of many other genes, with 3,012 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPS8-associated genes across cancer lineages are RNU6-898P, MIR6870, and NFYAP1. Each is linked with EPS8 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPS8-to-partner and partner-to-EPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-898P grouped by EPS8-low versus EPS8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS8→partner) and Y-score (partner→EPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-898P →	+0.223	+3.211	<.001	.008	3	3
OV	MIR6870 →	+0.696	+4.654	<.001	.001	3	2
CESC	NFYAP1 →	+0.234	+3.595	<.001	.005	3	2
CESC	VTRNA2-2P →	+0.348	+4.338	<.001	<.001	3	2
CESC	MIR4510 →	+0.167	+4.020	<.001	.009	3	2
SKCM	PPATP1 →	+0.063	+3.460	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,012 associations by consensus.

RNU6-898P by EPS8 expression — LUSC

Explore this box plot interactively →