EPS15L1

Across TCGA pan-cancer cohorts, EPS15L1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EPS15L1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EPS15L1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPS15L1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where EPS15L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.511	0.841	.001	33	view →
LUAD	OS	Median	II,III,IV	0.906	0.342	.005	20	view →
UCEC	OS	Median	II,III,IV	0.595	1.000	.005	20	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
GBM	OS	Quartile	All	0.518	0.253	.023	4	view →
LSCC	DFS	Median	III,IV	0.611	0.914	.042	3	view →
PDAC	DFS	Tertile	All	0.816	0.672	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EPS15L1–HNSC (DFS)

Open the HNSC breakdown →