EPS15L1

Across TCGA pan-cancer cohorts, EPS15L1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EPS15L1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EPS15L1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EPS15L1 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where EPS15L1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPS15L1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.506	<.001	11	view →
KIRP	Male	II,III,IV	+0.790	<.001	10	view →
LIHC	Female	II,III,IV	+1.409	<.001	9	view →
THCA	Male	II,III,IV	−0.505	<.001	9	view →
KIRC	Female	All	+0.441	<.001	9	view →
KICH	All	II,III,IV	+0.643	<.001	7	view →
BRCA	All	II,III,IV	+0.630	<.001	6	view →
LUSC	Female	All	+0.621	<.001	6	view →
CHOL	Male	All	+1.846	<.001	5	view →
COAD	All	II,III,IV	+0.207	.002	4	view →
BLCA	Male	IV	−0.459	.003	2	view →
STAD	Male	II,III,IV	+0.491	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EPS15L1–HNSC

Open the HNSC breakdown →