EPS15L1

Across TCGA patient cohorts, EPS15L1 mutation is significantly associated with the RNA expression of many other genes, with 4,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPS15L1-associated genes across cancer lineages are MIR4525, GOT1, and RPS29P10. Each is linked with EPS15L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPS15L1-to-partner and partner-to-EPS15L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4525 grouped by EPS15L1-low versus EPS15L1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS15L1→partner) and Y-score (partner→EPS15L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4525 →	+0.694	+4.221	<.001	.009	3	3
SKCM	GOT1 →	+0.443	+1.938	.003	.009	3	3
LUAD	RPS29P10 →	+0.202	+3.896	.007	.002	3	3
UCEC	GOLGA6L11P →	+0.007	+2.591	<.001	.003	3	3
COAD	SNORD31B →	+0.593	+5.136	<.001	.002	3	2
COAD	RNU6-1254P →	+0.978	+4.126	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,212 associations by consensus.

MIR4525 by EPS15L1 expression — HNSC

Explore this box plot interactively →