EPS15L1

Across TCGA cell cohorts, EPS15L1 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPS15L1-associated genes across cancer lineages are CST2, PTX4, and EFCAB3. Each is linked with EPS15L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPS15L1-to-partner and partner-to-EPS15L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST2 grouped by EPS15L1-low versus EPS15L1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS15L1→partner) and Y-score (partner→EPS15L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CST2 →	+0.228	+4.070	<.001	.004	3	2
LARGE_INTESTINE	PTX4 →	+0.097	+2.350	<.001	.005	3	2
OESOPHAGUS	EFCAB3 →	+0.006	+4.906	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

CST2 by EPS15L1 expression — BLOOD_Lymphoma

Explore this box plot interactively →