EPS15L1

Across TCGA cell cohorts, EPS15L1 mutation is significantly associated with the mutation status of many other genes, with 2,452 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPS15L1-associated genes across cancer lineages are ERBB2, XIRP1, and MAST1. Each is linked with EPS15L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPS15L1-to-partner and partner-to-EPS15L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERBB2 grouped by EPS15L1-low versus EPS15L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS15L1→partner) and Y-score (partner→EPS15L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ERBB2 →	+2.736	+3.050	<.001	<.001	1	4
LARGE_INTESTINE	XIRP1 →	+2.129	+2.411	.001	.001	1	4
LARGE_INTESTINE	MAST1 →	+1.906	+2.050	.009	.009	1	4
BREAST	ADGRA2 →	+4.297	+4.857	.009	.009	1	3
BLOOD_Lymphoma	UBR5 →	+3.554	+3.731	.003	.003	1	3
BLOOD_Lymphoma	ABCB6 →	+4.969	+4.014	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,452 associations by consensus.

ERBB2 by EPS15L1 expression — LARGE_INTESTINE

Explore this box plot interactively →