EPS15

Across TCGA patient cohorts, EPS15 mutation is significantly associated with the RNA expression of many other genes, with 4,106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPS15-associated genes across cancer lineages are OR6K5P, RN7SL578P, and MIR4774. Each is linked with EPS15 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPS15-to-partner and partner-to-EPS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K5P grouped by EPS15-low versus EPS15-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS15→partner) and Y-score (partner→EPS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	OR6K5P →	+0.057	+6.257	<.001	.001	3	2
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	2
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
BRCA	LINC02283 →	+0.085	+5.403	<.001	.001	3	2
CESC	MIR3926-1 →	+0.532	+3.269	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,106 associations by consensus.

OR6K5P by EPS15 expression — READ

Explore this box plot interactively →