EPS15

Across TCGA pan-cancer cohorts, EPS15 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EPS15’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where EPS15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EPS15 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LIHC, KICH, and THCA are the cancer types where EPS15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPS15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	III,IV	+0.612	<.001	9	view →
KICH	Female	All	−1.110	<.001	7	view →
THCA	All	All	−0.320	<.001	7	view →
HNSC	Female	III,IV	+0.784	.002	6	view →
LUSC	Male	All	−0.556	<.001	6	view →
LUAD	Female	II,III,IV	−0.538	<.001	6	view →
BRCA	Female	All	−0.221	<.001	6	view →
UCEC	All	All	−0.860	<.001	4	view →
CHOL	All	All	+1.092	<.001	3	view →
READ	All	All	−0.510	.012	2	view →
KIRP	Male	All	−0.419	.001	2	view →
PRAD	All	All	+0.230	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EPS15–LIHC

Open the LIHC breakdown →