EPS15

Across TCGA cell cohorts, EPS15 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPS15-associated genes across cancer lineages are TCP11X1, GCAT, and ZMYND8. Each is linked with EPS15 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPS15-to-partner and partner-to-EPS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP11X1 grouped by EPS15-low versus EPS15-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS15→partner) and Y-score (partner→EPS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TCP11X1 →	+0.013	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GCAT →	+1.319	+3.502	<.001	.001	3	1
LARGE_INTESTINE	ZMYND8 →	-0.825	-3.416	.001	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.287	+2.667	<.001	.007	3	1
LARGE_INTESTINE	C1QBP →	+0.657	+3.131	.003	.008	3	1
LARGE_INTESTINE	CTH →	+1.115	+3.502	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

TCP11X1 by EPS15 expression — SKIN

Explore this box plot interactively →