EPPIN

Across TCGA patient cohorts, EPPIN protein abundance is significantly associated with the RNA expression of many other genes, with 399 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EPPIN-associated genes across cancer lineages are SOS2, PPM1A, and DICER1. Each is linked with EPPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both EPPIN-to-partner and partner-to-EPPIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPPIN versus SOS2 in GBM, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPPIN→partner) and Y-score (partner→EPPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOS2 →	+0.674	+1.160	<.001	.004	3	1
GBM	PPM1A →	+0.767	+1.160	<.001	.004	3	1
GBM	DICER1 →	+0.530	+1.159	.005	.004	3	1
GBM	CCM2L →	+1.133	+1.543	<.001	.006	3	1
GBM	MON1B →	+0.193	+1.159	.004	.004	3	1
GBM	SLC30A4 →	+0.812	+1.160	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

EPPIN vs SOS2 — GBM

Explore this scatter interactively →