EPPIN

Across TCGA pan-cancer cohorts, EPPIN RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated EPPIN data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EPPIN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPPIN expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

KIRC, COAD, and HNSC are the cancer types where EPPIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.514	0.692	<.001	99	view →
COAD	OS	Tertile	All	0.698	0.850	<.001	93	view →
HNSC	OS	Tertile	IV	0.577	0.277	.003	62	view →
UCEC	DFS	Tertile	All	0.952	0.852	<.001	34	view →
LIHC	OS	Tertile	All	0.609	0.811	<.001	33	view →
THCA	OS	Quartile	II,III,IV	0.882	0.983	.003	23	view →
LUAD	OS	Quartile	All	0.899	0.770	<.001	20	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
PRAD	DFS	Median	All	0.904	0.649	.003	18	view →
GBM	DFS	Tertile	All	0.270	0.183	.033	9	view →
SCLC	DFS	Median	All	0.381	0.165	.032	8	view →
OV	DFS	Tertile	IV	0.403	0.601	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

EPPIN–KIRC (DFS)

Open the KIRC breakdown →