EPPIN

Across TCGA patient cohorts, EPPIN mutation is significantly associated with the RNA expression of many other genes, with 1,699 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPPIN-associated genes across cancer lineages are MRPS18BP1, RAD51C, and SDHB. Each is linked with EPPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both EPPIN-to-partner and partner-to-EPPIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS18BP1 grouped by EPPIN-low versus EPPIN-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPPIN→partner) and Y-score (partner→EPPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPS18BP1 →	+0.171	+6.112	<.001	.002	3	2
UCEC	RAD51C →	+0.556	+2.818	<.001	.001	3	2
UCEC	SDHB →	+0.418	+3.499	.009	.002	3	2
UCEC	ACYP1 →	+0.655	+2.828	<.001	.001	3	2
UCEC	CUTC →	+0.455	+3.502	.001	.002	3	2
UCEC	TRAF2 →	+0.438	+2.740	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,699 associations by consensus.

MRPS18BP1 by EPPIN expression — BRCA

Explore this box plot interactively →