EPPIN-WFDC6

Across TCGA pan-cancer cohorts, EPPIN-WFDC6 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated EPPIN-WFDC6 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EPPIN-WFDC6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPPIN-WFDC6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

KIRC, LUAD, and STAD are the cancer types where EPPIN-WFDC6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.275	0.662	.008	84	view →
LUAD	DFS	Tertile	All	0.859	0.757	.002	59	view →
STAD	DFS	Tertile	IV	0.087	0.415	<.001	45	view →
KIRP	DFS	Tertile	IV	0.088	0.502	<.001	36	view →
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →
SKCM	DFS	Tertile	II,III,IV	0.568	0.244	.014	27	view →
UCS	DFS	Median	IV	0.952	0.473	.018	24	view →
OV	DFS	Median	All	0.578	0.507	.015	22	view →
TGCT	DFS	Median	All	0.930	0.736	.002	18	view →
UCEC	OS	Tertile	All	0.960	0.903	.009	14	view →
PAAD	OS	Tertile	II,III,IV	0.288	0.569	.003	9	view →
BLCA	OS	Tertile	IV	0.227	0.595	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

EPPIN-WFDC6–KIRC (DFS)

Open the KIRC breakdown →