EPOP

Across TCGA cell cohorts, EPOP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,580 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EPOP-associated GO terms across cancer lineages are Regulation of transcription by RNA polymerase I, Protein-DNA complex disassembly, and Ribosomal small subunit biogenesis. Each is linked with EPOP in more than 13 cancer types. Because this analysis shows association rather than direction, both EPOP-to-partner and partner-to-EPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription by RNA polymerase I grouped by EPOP-low versus EPOP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPOP→partner) and Y-score (partner→EPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription by RNA polymerase I →	+0.164	+1.971	<.001	<.001	3	14
BONE	Protein-DNA complex disassembly →	+0.136	+1.214	<.001	<.001	3	12
BONE	Ribosomal small subunit biogenesis →	+0.156	+2.044	<.001	<.001	3	12
BONE	Nucleosome disassembly →	+0.190	+1.854	.002	<.001	3	12
BONE	DNA-templated transcription initiation →	+0.082	+1.715	.004	.004	3	12
BONE	rRNA metabolic process →	+0.165	+2.248	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,580 associations by consensus.

Regulation of transcription by RNA polymerase I by EPOP expression — BONE

Explore this box plot interactively →