EPOP

Across TCGA pan-cancer cohorts, EPOP RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EPOP data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher EPOP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPOP expression acts as an unfavorable survival marker, although some lineages such as LGG and LUSC show a favorable association.

KIRP, KIRC, and UVM are the cancer types where EPOP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.830	0.980	<.001	154	view →
KIRC	DFS	Median	All	0.555	0.690	<.001	108	view →
UVM	OS	Tertile	All	0.352	0.802	<.001	85	view →
MESO	OS	Tertile	II,III,IV	0.279	0.583	<.001	84	view →
ACC	DFS	Median	All	0.377	0.780	<.001	75	view →
LGG	DFS	Median	All	0.830	0.646	<.001	52	view →
UCEC	DFS	Median	All	0.789	0.883	<.001	38	view →
COAD	DFS	Quartile	II,III,IV	0.399	0.770	.002	34	view →
HNSC	DFS	Quartile	All	0.520	0.688	.001	32	view →
LAML	DFS	Median	All	0.278	0.642	<.001	28	view →
LUSC	OS	Median	All	0.464	0.327	.005	20	view →
OV	OS	Median	All	0.798	0.880	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EPOP–KIRP (DFS)

Open the KIRP breakdown →