EPOP

Across TCGA cell cohorts, EPOP mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible EPOP-associated genes across cancer lineages are USP29, PROP1, and OOSP4B. Each is linked with EPOP in more than 1 cancer types. Because this analysis shows association rather than direction, both EPOP-to-partner and partner-to-EPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by EPOP-low versus EPOP-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPOP→partner) and Y-score (partner→EPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PROP1 →	+0.028	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.017	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

USP29 by EPOP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →