EPO

Across TCGA patient cohorts, EPO mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPO-associated genes across cancer lineages are MSC, mv Endothelial cells, and Endothelial cells. Each is linked with EPO in more than 1 cancer types. Because this analysis shows association rather than direction, both EPO-to-partner and partner-to-EPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSC grouped by EPO-low versus EPO-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPO→partner) and Y-score (partner→EPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MSC →	+0.185	+2.820	.046	.035	3	1
UCEC	mv Endothelial cells →	-0.028	-3.000	.014	.036	3	1
UCEC	Endothelial cells →	-0.045	-2.416	.014	.021	1	1
UCEC	Mast cells →	+0.016	+2.502	.040	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MSC by EPO expression — SKCM

Explore this box plot interactively →