EPO

Across TCGA pan-cancer cohorts, EPO RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of EPO’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EPO RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EPO is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where EPO tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPO RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.193	<.001	12	view →
KIRC	All	All	+1.617	<.001	8	view →
KIRP	All	All	−0.700	<.001	7	view →
BRCA	Female	II,III,IV	+0.701	<.001	6	view →
LUSC	Male	All	+0.366	<.001	4	view →
KICH	All	All	−0.455	.006	3	view →
LIHC	All	All	−1.126	<.001	2	view →
CHOL	All	All	−0.936	.019	2	view →
UCEC	All	All	−0.639	.009	2	view →
PRAD	All	All	−0.312	.047	2	view →
COAD	Female	All	+0.079	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

EPO–HNSC

Open the HNSC breakdown →