EPO

Across TCGA cell cohorts, EPO RNA expression is significantly associated with the go_rna of many other GO terms, with 1,846 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EPO-associated GO terms across cancer lineages are RNA export from nucleus, mRNA transport, and Regulation of DNA repair. Each is linked with EPO in more than 7 cancer types. Because this analysis shows association rather than direction, both EPO-to-partner and partner-to-EPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA export from nucleus grouped by EPO-low versus EPO-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPO→partner) and Y-score (partner→EPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA export from nucleus →	+0.090	+0.099	.001	.001	3	8
BONE	mRNA transport →	+0.103	+0.139	.002	<.001	3	7
BONE	Regulation of DNA repair →	+0.062	+0.071	<.001	.007	3	7
SOFT_TISSUE	Nuclear export →	+0.076	+0.080	<.001	.002	3	6
OVARY	U2-type prespliceosome assembly →	+0.075	+0.056	.008	<.001	2	7
BONE	Cardiac muscle contraction →	-0.062	-0.090	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,846 associations by consensus.

RNA export from nucleus by EPO expression — BONE

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