EPHX4

Across TCGA patient cohorts, EPHX4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHX4-associated genes across cancer lineages are ASNS, ATM, and EGFR_pY1068. Each is linked with EPHX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX4-to-partner and partner-to-EPHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EPHX4-low versus EPHX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX4→partner) and Y-score (partner→EPHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.477	+2.115	<.001	.017	3	2
UCEC	ATM →	-0.467	-1.415	.006	.046	3	2
UCEC	EGFR_pY1068 →	-0.286	-2.906	.002	.001	3	1
UCEC	eIF4E →	+0.158	+2.700	.046	.006	3	1
UCEC	A-Raf_pS299 →	-0.096	-1.765	.032	.014	3	1
UCEC	ERK2 →	+0.155	+1.765	.032	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by EPHX4 expression — UCEC

Explore this box plot interactively →