EPHX4

Across TCGA pan-cancer cohorts, EPHX4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated EPHX4 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher EPHX4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EPHX4 expression acts as an unfavorable survival marker, although some lineages such as READ and COAD show a favorable association.

KIRP, UCEC, and PAAD are the cancer types where EPHX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.673	0.865	<.001	131	view →
UCEC	OS	Median	All	0.523	0.838	<.001	106	view →
PAAD	DFS	Tertile	All	0.167	0.461	<.001	71	view →
MESO	DFS	Tertile	All	0.182	0.401	.002	60	view →
LIHC	OS	Tertile	All	0.586	0.764	<.001	56	view →
UCS	OS	Median	IV	0.302	0.817	.002	50	view →
HNSC	OS	Quartile	IV	0.264	0.706	.003	49	view →
READ	OS	Median	II,III,IV	0.972	0.848	.002	40	view →
LUSC	DFS	Tertile	III,IV	0.373	0.638	.016	25	view →
KICH	OS	Tertile	All	0.667	1.000	.014	13	view →
SKCM	DFS	Quartile	III,IV	0.157	0.356	.005	9	view →
COAD	OS	Quartile	IV	0.745	0.380	.017	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

EPHX4–KIRP (OS)

Open the KIRP breakdown →