EPHX4

Across TCGA cell cohorts, EPHX4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHX4-associated genes across cancer lineages are TTLL8, PATE4, and OR1E2. Each is linked with EPHX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX4-to-partner and partner-to-EPHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by EPHX4-low versus EPHX4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX4→partner) and Y-score (partner→EPHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PATE4 →	+0.041	+4.095	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1E2 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.076	+4.887	<.001	.009	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.123	+4.108	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TTLL8 by EPHX4 expression — LARGE_INTESTINE

Explore this box plot interactively →