EPHX3

Across TCGA patient cohorts, EPHX3 mutation is significantly associated with the RNA expression of many other genes, with 299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHX3-associated genes across cancer lineages are RNU6-792P, MRPL51P2, and PRR23D1. Each is linked with EPHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX3-to-partner and partner-to-EPHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-792P grouped by EPHX3-low versus EPHX3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX3→partner) and Y-score (partner→EPHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-792P →	+0.176	+4.444	<.001	.006	3	2
LUAD	MRPL51P2 →	+0.073	+5.584	<.001	.002	3	2
STAD	PRR23D1 →	+0.027	+5.465	<.001	<.001	3	2
UCEC	EIF3JP1 →	+0.203	+2.883	<.001	<.001	3	2
UCEC	MIR4451 →	+0.247	+2.589	.007	.008	3	2
LUSC	RNA5SP408 →	+1.013	+6.918	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

RNU6-792P by EPHX3 expression — BLCA

Explore this box plot interactively →