EPHX3

Across TCGA pan-cancer cohorts, EPHX3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EPHX3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EPHX3 RNA is repressed in tumor relative to normal tissue. In most cancer types EPHX3 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where EPHX3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPHX3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	−3.508	<.001	12	view →
THCA	Female	All	+0.931	<.001	10	view →
COAD	Male	III,IV	+0.661	<.001	10	view →
LUAD	Female	III,IV	+2.377	<.001	9	view →
KICH	Male	II,III,IV	−1.838	<.001	9	view →
LUSC	Female	All	+1.226	.004	5	view →
KIRC	Male	II,III,IV	−0.887	<.001	5	view →
READ	Male	All	+1.123	.018	4	view →
KIRP	All	All	−0.953	.001	4	view →
LIHC	All	All	+0.221	.020	3	view →
CHOL	All	All	+2.405	<.001	2	view →
PRAD	All	All	−0.605	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EPHX3–HNSC

Open the HNSC breakdown →