EPHX3

Across TCGA patient cohorts, EPHX3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHX3-associated genes across cancer lineages are mTOR_pS2448, FOXO3a_pS318_S321, and Ku80. Each is linked with EPHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX3-to-partner and partner-to-EPHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by EPHX3-low versus EPHX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX3→partner) and Y-score (partner→EPHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.172	-3.169	.035	.020	3	2
UCEC	FOXO3a_pS318_S321 →	-0.136	-3.169	.047	.020	3	1
UCEC	Ku80 →	+0.324	+3.183	.012	.010	3	1
UCEC	Notch1 →	+0.191	+3.169	.013	.020	3	1
UCEC	14-3-3_epsilon →	+0.116	+2.817	.033	.036	3	1
UCEC	Rb_pS807_S811 →	-0.617	-3.169	.005	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

mTOR_pS2448 by EPHX3 expression — UCEC

Explore this box plot interactively →