EPHX3

Across TCGA cell cohorts, EPHX3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EPHX3-associated genes across cancer lineages are TBX22, APOL5, and RHCG. Each is linked with EPHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX3-to-partner and partner-to-EPHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX22 grouped by EPHX3-low versus EPHX3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX3→partner) and Y-score (partner→EPHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TBX22 →	+0.036	+5.369	<.001	.004	3	1
BLOOD_Leukemia	APOL5 →	+0.018	+4.060	<.001	.003	3	1
BLOOD_Leukemia	RHCG →	+0.113	+3.729	<.001	.009	3	1
BLOOD_Leukemia	SLC22A3 →	+0.078	+4.037	<.001	.004	3	1
BLOOD_Leukemia	TACR3 →	+0.036	+5.475	<.001	<.001	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TBX22 by EPHX3 expression — SOFT_TISSUE

Explore this box plot interactively →