EPHB1

Across TCGA patient cohorts, EPHB1 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHB1-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH6, and HSP70. Each is linked with EPHB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPHB1-to-partner and partner-to-EPHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EPHB1-low versus EPHB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB1→partner) and Y-score (partner→EPHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.556	+1.505	<.001	.001	3	4
LUAD	MSH6 →	+0.316	+2.832	.020	.034	3	3
BRCA	HSP70 →	-0.620	-2.316	.013	.036	3	3
LUSC	Cyclin-B1 →	+0.545	+3.584	.001	.002	3	3
COAD	PDCD4 →	-0.364	-2.305	.014	.032	3	3
UCEC	eEF2 →	+0.183	+1.440	.042	.020	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Caspase-7-cleavedD198 by EPHB1 expression — UCEC

Explore this box plot interactively →