EPHB1

Across TCGA pan-cancer cohorts, EPHB1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated EPHB1 data layer compared with 12 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher EPHB1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EPHB1 expression acts as an unfavorable survival marker, although some lineages such as LGG and ACC show a favorable association.

BLCA, UCEC, and LGG are the cancer types where EPHB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.291	0.519	<.001	97	view →
UCEC	DFS	Median	All	0.576	0.711	<.001	62	view →
LGG	DFS	Median	All	0.837	0.635	<.001	44	view →
ACC	OS	Quartile	II,III,IV	0.842	0.587	.015	22	view →
COAD	DFS	Median	All	0.353	0.576	.008	20	view →
CHOL	DFS	Tertile	All	0.748	0.125	.004	18	view →
UVM	DFS	Quartile	II,III,IV	0.461	0.874	.027	16	view →
CESC	DFS	Median	IV	0.090	0.431	.027	14	view →
PRAD	DFS	Tertile	All	0.974	0.906	.005	12	view →
SCLC	DFS	Median	III,IV	0.968	0.338	.024	6	view →
LUSC	DFS	Quartile	III,IV	0.290	1.000	.011	6	view →
THYM	DFS	Median	All	0.967	0.839	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

EPHB1–BLCA (OS)

Open the BLCA breakdown →