EPHB1

Across TCGA cell cohorts, EPHB1 mutation is significantly associated with the RNA expression of many other genes, with 316 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHB1-associated genes across cancer lineages are IFNA7, CPXCR1, and TNP2. Each is linked with EPHB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHB1-to-partner and partner-to-EPHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA7 grouped by EPHB1-low versus EPHB1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB1→partner) and Y-score (partner→EPHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFNA7 →	+0.094	+4.035	<.001	.006	3	2
LUNG_SCLC	CPXCR1 →	+0.042	+4.392	<.001	<.001	3	2
OESOPHAGUS	TNP2 →	+0.023	+4.392	<.001	.003	3	1
OESOPHAGUS	LRRC3B →	+0.058	+4.392	<.001	.003	3	1
OESOPHAGUS	VWC2 →	+0.080	+4.857	<.001	<.001	3	1
PANCREAS	TSPY4 →	+0.050	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 316 associations by consensus.

IFNA7 by EPHB1 expression — CNS

Explore this box plot interactively →