EPHA5

Across TCGA patient cohorts, EPHA5 protein abundance is significantly associated with the RNA expression of many other genes, with 2,877 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible EPHA5-associated genes across cancer lineages are PPP1R16B, PACSIN1, and ITM2C. Each is linked with EPHA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHA5-to-partner and partner-to-EPHA5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPHA5 versus PPP1R16B in HNSC, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA5→partner) and Y-score (partner→EPHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R16B →	+1.591	+1.162	<.001	<.001	3	2
GBM	PACSIN1 →	+0.937	+0.354	.004	<.001	3	2
HNSC	ITM2C →	+0.821	+0.806	<.001	.001	3	2
HNSC	CCDC141 →	+0.941	+1.020	<.001	<.001	3	2
HNSC	PNOC →	+0.877	+0.963	.002	.002	3	2
GBM	C4orf50 →	+0.895	+0.575	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,877 associations by consensus.

EPHA5 vs PPP1R16B — HNSC

Explore this scatter interactively →