EPHA5

Across TCGA pan-cancer cohorts, EPHA5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EPHA5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where EPHA5 RNA is repressed in tumor relative to normal tissue. In most cancer types EPHA5 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BLCA are the cancer types where EPHA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPHA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.784	<.001	11	view →
COAD	Female	II,III,IV	−0.175	<.001	10	view →
BLCA	All	All	−0.278	.006	8	view →
UCEC	All	All	−0.362	<.001	6	view →
READ	All	All	−0.277	.003	6	view →
LUAD	All	III,IV	−0.069	.004	4	view →
HNSC	All	All	−0.048	.005	4	view →
BRCA	All	All	−0.037	.001	4	view →
KIRC	Male	All	−0.088	<.001	3	view →
STAD	All	All	−0.161	.012	2	view →
KICH	Female	II,III,IV	−0.040	<.001	2	view →
LIHC	All	II,III,IV	+0.006	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EPHA5–THCA

Open the THCA breakdown →