EPHA5

Across TCGA cell cohorts, EPHA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,708 significant associations in total. CNS shows the largest number of these associations.

The most reproducible EPHA5-associated GO terms across cancer lineages are Positive regulation of potassium ion import across plasma membrane, Positive regulation of cell-substrate junction organization, and Negative regulation of bone mineralization involved in bone maturation. Each is linked with EPHA5 in more than 6 cancer types. Because this analysis shows association rather than direction, both EPHA5-to-partner and partner-to-EPHA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of potassium ion import across plasma membrane grouped by EPHA5-low versus EPHA5-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA5→partner) and Y-score (partner→EPHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of potassium ion import across plasma membrane →	-0.157	-0.719	<.001	.005	3	7
CNS	Positive regulation of cell-substrate junction organization →	+0.109	+1.115	<.001	.005	3	6
BREAST	Negative regulation of bone mineralization involved in bone maturation →	+1.541	+0.944	<.001	.005	3	6
LUNG_SCLC	Ascending thin limb development →	+0.191	+1.356	.001	.001	3	6
LUNG_SCLC	Metanephric ascending thin limb development →	+0.191	+1.356	.001	.001	3	6
BREAST	Negative regulation of endodermal cell differentiation →	+1.035	+0.880	.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,708 associations by consensus.

Positive regulation of potassium ion import across plasma membrane by EPHA5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →