EPHA5

Across TCGA cell cohorts, EPHA5 mutation is significantly associated with the RNA expression of many other genes, with 2,047 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA5-associated genes across cancer lineages are OR1L6, ATPAF1, and GAD2. Each is linked with EPHA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHA5-to-partner and partner-to-EPHA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by EPHA5-low versus EPHA5-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA5→partner) and Y-score (partner→EPHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.015	+4.169	<.001	.008	3	3
LARGE_INTESTINE	ATPAF1 →	+0.702	+3.043	<.001	<.001	3	3
LUNG_NSCLC_LUSC	GAD2 →	+0.038	+2.836	.009	.004	3	2
LUNG_NSCLC_LUSC	GPR151 →	+0.049	+2.836	.003	.004	3	2
LUNG_NSCLC_LUSC	OR52B2 →	+0.047	+2.552	<.001	.008	3	2
STOMACH	MRGPRX4 →	+0.095	+4.129	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,047 associations by consensus.

OR1L6 by EPHA5 expression — BONE

Explore this box plot interactively →