EPHA2

Across TCGA patient cohorts, EPHA2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,111 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible EPHA2-associated genes across cancer lineages are KRT16, GJB3, and MROH6. Each is linked with EPHA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both EPHA2-to-partner and partner-to-EPHA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPHA2 versus KRT16 in HNSC, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA2→partner) and Y-score (partner→EPHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRT16 →	+2.010	+0.474	<.001	<.001	3	5
HNSC	GJB3 →	+1.355	+0.570	<.001	<.001	3	5
LSCC	MROH6 →	+0.851	+0.500	<.001	<.001	3	5
PDAC	ANXA8L1 →	+1.120	+0.387	.002	.006	3	5
OV	SH3BGRL3 →	+0.734	+0.550	<.001	<.001	3	5
BRCA	LY9 →	-0.855	-0.780	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,111 associations by consensus.

EPHA2 vs KRT16 — HNSC

Explore this scatter interactively →