EPHA2

Across TCGA pan-cancer cohorts, EPHA2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated EPHA2 data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher EPHA2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPHA2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

SKCM, PAAD, and LGG are the cancer types where EPHA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Quartile	II,III,IV	0.202	0.332	.001	58	view →
PAAD	OS	Median	All	0.346	0.685	<.001	57	view →
LGG	OS	Median	All	0.715	0.910	<.001	54	view →
LUAD	DFS	Median	IV	0.489	0.887	.001	46	view →
LUSC	OS	Tertile	All	0.709	0.828	.001	37	view →
COAD	DFS	Tertile	II,III,IV	0.282	0.633	.004	34	view →
KIRC	OS	Quartile	All	0.716	0.510	.003	29	view →
THYM	DFS	Tertile	All	1.000	0.668	.011	21	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	15	view →
DLBC	DFS	Median	All	0.630	0.917	.012	15	view →
TGCT	DFS	Median	All	0.751	0.915	.021	14	view →
THCA	DFS	Median	All	0.913	0.629	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

EPHA2–SKCM (DFS)

Open the SKCM breakdown →