EPHA2

Across TCGA patient cohorts, EPHA2 mutation is significantly associated with the RNA expression of many other genes, with 5,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA2-associated genes across cancer lineages are SAAL1, PGAM1, and RAD51. Each is linked with EPHA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPHA2-to-partner and partner-to-EPHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAAL1 grouped by EPHA2-low versus EPHA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA2→partner) and Y-score (partner→EPHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAAL1 →	+0.574	+2.080	<.001	<.001	3	4
UCEC	PGAM1 →	+0.929	+2.112	<.001	<.001	3	4
UCEC	RAD51 →	+0.836	+2.389	<.001	<.001	3	4
UCEC	CCM2L →	-0.410	-1.766	.003	.002	3	3
SKCM	GUCA1B →	+0.504	+2.254	.001	.001	3	3
SKCM	ADRA2A →	-0.840	-2.797	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,129 associations by consensus.

SAAL1 by EPHA2 expression — UCEC

Explore this box plot interactively →