EPHA2

Across TCGA cell cohorts, EPHA2 mutation is significantly associated with the RNA expression of many other genes, with 1,288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA2-associated genes across cancer lineages are TAS2R39, NPY5R, and OR6C70. Each is linked with EPHA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHA2-to-partner and partner-to-EPHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R39 grouped by EPHA2-low versus EPHA2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA2→partner) and Y-score (partner→EPHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TAS2R39 →	+0.043	+4.906	<.001	.006	3	3
PANCREAS	NPY5R →	+0.340	+4.011	<.001	.009	3	2
BLOOD_Myeloma	OR6C70 →	+0.073	+4.807	<.001	.006	3	2
PANCREAS	OR10Q1 →	+0.025	+4.614	<.001	.004	3	2
BLOOD_Leukemia	LRRC3C →	+0.074	+3.118	.001	.005	3	2
LARGE_INTESTINE	PAK6 →	+1.094	+3.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,288 associations by consensus.

TAS2R39 by EPHA2 expression — OESOPHAGUS

Explore this box plot interactively →