EPHA1

Across TCGA cell cohorts, EPHA1 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA1-associated genes across cancer lineages are GPX5, LRRC73, and TULP3. Each is linked with EPHA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHA1-to-partner and partner-to-EPHA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX5 grouped by EPHA1-low versus EPHA1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA1→partner) and Y-score (partner→EPHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPX5 →	+0.014	+3.058	.002	.004	3	2
BLOOD_Leukemia	LRRC73 →	+0.080	+3.334	.001	.008	3	2
LARGE_INTESTINE	TULP3 →	+0.764	+3.212	.003	.006	3	2
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
OVARY	IL17F →	+0.033	+3.417	.001	.001	3	1
OVARY	GUCA1C →	+0.669	+3.963	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

GPX5 by EPHA1 expression — OVARY

Explore this box plot interactively →