EPGN

Across TCGA patient cohorts, EPGN mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPGN-associated genes across cancer lineages are Myosin-IIa, Src_pY416, and Tuberin. Each is linked with EPGN in more than 1 cancer types. Because this analysis shows association rather than direction, both EPGN-to-partner and partner-to-EPGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa grouped by EPGN-low versus EPGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPGN→partner) and Y-score (partner→EPGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa →	+0.244	+2.814	.031	.036	3	1
UCEC	Src_pY416 →	-0.308	-2.986	.027	.037	3	1
UCEC	Tuberin →	+0.473	+2.817	.002	.036	3	1
UCEC	C-Raf →	+0.239	+3.000	.003	.037	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.681	+3.000	.020	.037	2	1
UCEC	Caspase-8 →	-0.312	-3.000	.032	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Myosin-IIa by EPGN expression — UCEC

Explore this box plot interactively →