EPGN

Across TCGA pan-cancer cohorts, EPGN RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of EPGN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EPGN RNA is repressed in tumor relative to normal tissue. In most cancer types EPGN is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and KICH are the cancer types where EPGN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPGN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.611	<.001	12	view →
LUAD	All	All	−0.633	<.001	8	view →
KICH	All	All	−0.665	<.001	7	view →
READ	All	II,III,IV	+0.127	.001	6	view →
BRCA	All	All	+0.253	.006	4	view →
PRAD	All	All	−0.328	<.001	2	view →
THCA	Male	All	+0.110	.017	2	view →
CHOL	All	All	+0.098	.040	2	view →
COAD	All	II,III,IV	+0.043	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

EPGN–KIRC

Open the KIRC breakdown →