EPDR1

Across TCGA patient cohorts, EPDR1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPDR1-associated genes across cancer lineages are Rad50, TIGAR, and Tuberin. Each is linked with EPDR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPDR1-to-partner and partner-to-EPDR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by EPDR1-low versus EPDR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPDR1→partner) and Y-score (partner→EPDR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.310	-3.321	.014	.010	3	1
UCEC	TIGAR →	+0.199	+2.196	.012	.034	3	1
UCEC	Tuberin →	+0.357	+3.321	.011	.010	3	1
UCEC	ASNS →	+0.700	+3.169	<.001	.019	3	1
UCEC	4E-BP1 →	+0.479	+3.321	<.001	.010	2	1
UCEC	MEK1 →	+0.625	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Rad50 by EPDR1 expression — UCEC

Explore this box plot interactively →