EPCAM

Across TCGA patient cohorts, EPCAM mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPCAM-associated genes across cancer lineages are Macrophages, Th2 cells, and CD8+ T-cells. Each is linked with EPCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both EPCAM-to-partner and partner-to-EPCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophages grouped by EPCAM-low versus EPCAM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPCAM→partner) and Y-score (partner→EPCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Macrophages →	+0.026	+3.288	.017	.041	3	2
UCEC	Th2 cells →	+0.227	+2.818	.003	.035	3	2
HNSC	CD8+ T-cells →	+0.046	+4.015	<.001	.018	3	1
HNSC	Monocytes →	+0.023	+5.468	<.001	.002	3	1
HNSC	CD4+ naive T-cells →	+0.026	+4.368	<.001	.011	3	1
UCEC	Erythrocytes →	+0.031	+2.531	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Macrophages by EPCAM expression — COAD

Explore this box plot interactively →