EPCAM

Across TCGA pan-cancer cohorts, EPCAM RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of EPCAM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EPCAM RNA is repressed in tumor relative to normal tissue. In most cancer types EPCAM is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, BLCA, and LUAD are the cancer types where EPCAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPCAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.600	<.001	12	view →
BLCA	All	III,IV	+3.637	<.001	11	view →
LUAD	Male	II,III,IV	+1.859	<.001	11	view →
STAD	All	II,III,IV	+3.396	<.001	8	view →
HNSC	Male	IV	+3.209	<.001	8	view →
KICH	Male	All	−2.280	<.001	7	view →
KIRP	All	All	−2.121	<.001	7	view →
UCEC	All	All	+3.604	<.001	6	view →
BRCA	All	III,IV	+2.073	<.001	6	view →
CHOL	All	All	+5.955	<.001	5	view →
COAD	Female	All	−0.501	.008	3	view →
PRAD	All	All	+1.142	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

EPCAM–KIRC

Open the KIRC breakdown →