EPCAM

Across TCGA cell cohorts, EPCAM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,744 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible EPCAM-associated GO terms across cancer lineages are Desmosome maintenance, Bundle of His cell-Purkinje myocyte adhesion involved in cell communication, and Regulation of white fat cell proliferation. Each is linked with EPCAM in more than 12 cancer types. Because this analysis shows association rather than direction, both EPCAM-to-partner and partner-to-EPCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Desmosome maintenance grouped by EPCAM-low versus EPCAM-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPCAM→partner) and Y-score (partner→EPCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Desmosome maintenance →	+1.639	+4.961	<.001	<.001	3	13
URINARY_TRACT	Bundle of His cell-Purkinje myocyte adhesion involved in cell communication →	+0.668	+4.698	.005	<.001	3	12
LUNG_NSCLC_LUSC	Regulation of white fat cell proliferation →	-0.262	-4.197	<.001	<.001	3	11
LIVER	Keratinocyte development →	-0.491	-5.755	.001	<.001	3	11
URINARY_TRACT	Establishment of epithelial cell apical/basal polarity →	-0.249	-5.185	<.001	<.001	3	11
LUNG_SCLC	Negative regulation of cytokine activity →	-1.038	-5.053	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,744 associations by consensus.

Desmosome maintenance by EPCAM expression — OVARY

Explore this box plot interactively →